Research Outputs

PhD Theses and Doctor of Science Dissertations

These research projects reflect the department’s researcher training and the development of its core scientific programmes.

Scientific illustration for Graduate Training and Dissertations

Current PhD Research

Current doctoral projects undertaken within the department’s research programmes.

Current PhD research

Hanna VYSHNIAKOVA · PhD candidateSearch for Agents with Antistaphylococcal Activity against Staphylococcus aureus Strains Exhibiting Different Antibiotic-Resistance Phenotypes
This doctoral research focuses on identifying novel agents with antistaphylococcal activity against clinical Staphylococcus aureus strains exhibiting different antibiotic-resistance phenotypes. The study evaluates low-molecular-weight sortase A inhibitors, heterometallic complexes, plant extracts, bacteriophages and probiotic preparations.
The integrated approach combines microbiological and biochemical methods, molecular docking, and assessment of the ability of the investigated agents to inhibit bacterial growth and biofilm formation. The findings provide a scientific basis for developing alternative and adjunctive strategies to overcome multidrug resistance in S. aureus. Scientific supervisor — Professor Serhiy Yarmoluk.
Mykhailo MAHDYSIUK · PhD candidateDevelopment of Low-Molecular-Weight Inhibitors of Protein Kinase CK2
Mykhailo Mahdysiuk’s doctoral research focuses on identifying novel compounds capable of selectively inhibiting CK2, a promising therapeutic target in cancer, viral infections and other diseases. The study investigates aurone derivatives, 2,4-dianilinopyrimidines and other structural classes.
The research combines experimental assessment of inhibitory activity by capillary electrophoresis with molecular docking and molecular dynamics simulations. The findings advance understanding of structure–activity relationships and provide a basis for the further optimization of potential therapeutic agents. Scientific supervisor — Professor Serhiy Yarmoluk.
Oleksandr KAZAKOV-KRAVCHENKO · PhD candidateFluorescent Cyanine Dyes for Nucleic Acid Detection by PCR
Oleksandr Kazakov-Kravchenko’s doctoral research investigates relationships between the chemical structures of cyanine dyes, their spectral and luminescent properties, and their interactions with nucleic acids and proteins. Eighty compounds were examined using absorption and fluorescence spectroscopy, real-time PCR, DNA melting-curve analysis and gel electrophoresis.
Among the compounds studied, the monomethine cyanine dye fb128 exhibited high sensitivity for fluorescent DNA detection, only a minor effect on amplicon melting temperature, and virtually no inhibition of amplification within its optimal concentration range. Its analytical performance is comparable to that of the commercial dyes SYBR Green and EvaGreen, supporting its potential use as a fluorescent reporter for quantitative real-time PCR.

Archive of Defended Theses

A record of defended theses with abstracts, bibliographic details and principal findings.

Archive of defended theses

Select a dissertation to open its abstract, bibliographic record and principal findings.

01 · 2024 Zwitterionic Dyes as Probes for Fluorescence Imaging of Cells and Potential Reagents for Photodynamic Therapy
Ahnesa Tarasivna Syniuhina · defended 2024 · 091 — Biology
Abstract, bibliography and principal findings.
02 · 2021 Development of Bioavailable Protein Kinase CK2 Inhibitors
Mykola Vasylovych Protopopov · defended 2021 · 03.00.03 — Molecular Biology
Abstract, bibliography and principal findings.
03 · 2020 Interactions between Globular Proteins and Boron-Containing Cage Macrocyclic Complexes
Maryna Volodymyrivna Kuperman · defended 2020 · 03.00.03 — Molecular Biology
Abstract, bibliography and principal findings.
04 · 2019 Phthalocyanine Complexes with Axially Coordinated Substituents as Inhibitors of Amyloid Protein Aggregation
Svitlana Viktorivna Chernii · defended 2019 · 03.00.03 — Molecular Biology
Abstract, bibliography and principal findings.
05 · 2019 Novel FGFR1 and CK2 Protein Kinase Inhibitors Based on Thieno[2,3-d]pyrimidine Derivatives
Ihor Mykhailovych Kotei · defended 2019 · 02.00.10 — Bioorganic Chemistry
Abstract, bibliography and principal findings.
06 · 2019 Synthesis and Antitumor Activity of 2,5-Dihydropyrrole-2,5-dione and 1,2-Dihydropyrrol-3-one Derivatives
Serhii Stepanovych Tarnavskyi · defended 2019 · 02.00.10 — Bioorganic Chemistry
Abstract, bibliography and principal findings.
07 · 2017 Development of Pharmacophore Models and Inhibitors of ASK1, FGFR1 and CK2 Protein Kinases
Serhii Anatoliiovych Starosyla · defended 2017 · 03.00.03 — Molecular Biology
Abstract, bibliography and principal findings.
08 · 2017 Synthesis of Novel Protein Kinase CK2 Inhibitors Based on 3-Substituted Quinoline Derivatives
Anatolii Rostyslavovych Syniuhin · defended 2017 · 02.00.10 — Bioorganic Chemistry
Abstract, bibliography and principal findings.
09 · 2016 Discovery of Novel Protein Kinase CK2 Inhibitors among 4H-4-Chromenone Derivatives
Andrii Oleksandrovych Prykhodko · defended 2016 · 02.00.10 — Bioorganic Chemistry
Abstract, bibliography and principal findings.
10 · 2015 Development of Low-Molecular-Weight Protein Kinase CK2 Inhibitors
Olha Vasylivna Ostrynska · defended 2015 · 03.00.20 — Biotechnology
Abstract, bibliography and principal findings.
11 · 2014 Computer-Aided Design and Synthesis of 2-Phenylisothiazolidin-3-one 1,1-Dioxide and 2-Aminopyrimidinone Derivatives as Protein Kinase CK2 Inhibitors
Maksym Oleksandrovych Chekanov · defended 2014 · 02.00.10 — Bioorganic Chemistry
Abstract, bibliography and principal findings.
12 · 2013 In Silico Design of Protein Kinase ASK1 Inhibitors
Halyna Petrivna Volynets · defended 2013 · 03.00.20 — Biotechnology
Abstract, bibliography and principal findings.
13 · 2000 Fluorescent Dyes for Detection of Proteins with Different Spatial Organization
Vladyslava Borysivna Kovalska · defended 2000 · 02.00.10 — Bioorganic Chemistry
Abstract, bibliography and principal findings.
14 · 2009 Cyanine Dyes as Fluorescent Probes for Detection of Fibrillar Alpha-Synuclein
Kateryna Dmytrivna Volkova · defended 2009 · 03.00.20 — Biotechnology
Abstract, bibliography and principal findings.
15 · 2008 Technology for Predicting the Affinity of Organic Compounds for Molecular Biological Targets in Receptor-Based In Silico Screening
Oleksandr Yaroslavovych Yakovenko · defended 2008 · 03.00.20 — Biotechnology
Abstract, bibliography and principal findings.
16 · 2007 Styryl Cyanines for Fluorescence Detection of Nucleic Acids under One- and Two-Photon Excitation
Anatolii Oleksiiovych Balanda · defended 2007 · 02.00.10 — Bioorganic Chemistry
Abstract, bibliography and principal findings.
17 · 2007 In Silico Design of Protein Kinase CK2 Inhibitors
Andrii Hryhorovych Holub · defended 2007 · 03.00.03 — Molecular Biology
Abstract, bibliography and principal findings.
18 · 2005 Design of Cyanine-Based Fluorescent Probes for Nucleic Acids and Proteins
Serhii Mykolaiovych Yarmoluk · defended 2005 · 02.00.10 — Bioorganic Chemistry
Abstract, bibliography and principal findings.
19 · 2003 Sterically Constrained Cyanines for Fluorescence Detection of Nucleic Acids
Serhii Stepanovych Lukashov · defended 2003 · 02.00.10 — Bioorganic Chemistry
Abstract, bibliography and principal findings.
20 · 2003 Application of the Reaction of Pyrylocyanines with Amines in the Synthesis of Pyridocyanine–Biomolecule Conjugates
Oleksandr Mykolaiovych Kostenko · defended 2003 · 02.00.10 — Bioorganic Chemistry
Abstract, bibliography and principal findings.
21 · 2001 Synthesis and Physicochemical Characterization of Homo-n-meric Monomethine Cyanine Dyes as Highly Efficient Fluorescent Probes for Nucleic Acid Detection
Ihor Oleksandrovych Kocheshev · defended 2001 · 02.00.10 — Bioorganic Chemistry
Abstract, bibliography and principal findings.
22 · 2001 (Thio)(pyrido-4)monomethine Cyanines for Fluorescence Detection of Nucleic Acids and Proteins
Dmytro Valentynovych Kryvorotenko · defended 2001 · 02.00.10 — Bioorganic Chemistry
Abstract, bibliography and principal findings.
23 · 2000 Interactions of Monomethine Benzothiazole Cyanine Dyes with DNA Studied by Spectroscopic and Luminescence Methods
Vladyslava Borysivna Kovalska · defended 2000 · 03.00.03 — Molecular Biology
Abstract, bibliography and principal findings.

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We welcome collaboration on interdisciplinary biomedical research.

We are open to collaboration in joint research and applied projects, spanning computational modeling, analytical studies, and hypothesis testing to the publication of findings, joint grant applications, and product development.

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