Research Outputs

Selected Publications

Key and recent papers by our researchers reflecting the department’s principal scientific directions.

Research data from molecular modeling, fluorescence microscopy and medicinal-plant analysis converging into a scientific publication

Protein Kinase Inhibitors and Bioactive Compound Design

Protein kinase inhibitors, molecular modelling and the design, synthesis and evaluation of bioactive small molecules.

Discovery and Biological Characterization of 1-[4-(2-Difluoromethoxyphenyl)-5-methylthiazol-2-yl]-3-(naphthalen-1-yl)urea (DFMNTU): A Novel Thiazolyl-Urea Chemotype Targeting Yellow Fever Virus and Host Casein Kinase 2 (CK2)

Anatolii Demchenko, Artur Martynov, Galyna Volynets, Volodymyr Bdzhola, Mykhailo Mahdysiuk, Sergii Demchenko, Sergii Yarmoluk, Dmytro Zaporozhets, Volodymyr Sukhovieiev, Mariia Usenko, Oksana Gorbatiuk, Svitlana V Antonenko, Volodymyr Zaitsev

European Journal of Pharmaceutical Sciences. 2026 Oct 3:107679. Online ahead of print. PMID: 42829118

https://doi.org/10.1016/j.ejps.2026.107679

Synthesis and structure-activity relationship of 4,6-bis(pyrrolidin-1-yl)-1,3,5-triazines, their antiviral activity against yellow fever and Tacaribe viruses

Anatolii Demchenko, Artur Martynov, Yevhenii Novodvorskyi, Andrii Tsyhankov, Albina Mikhraliieva, Oleh Moskalenko, Oleh Yadlovskyi, Sergii Demchenko, Sergii Tsyhankov, Sergii Yarmoluk, Volodymyr Zaitsev

Results in Chemistry, August 2026, Volume 28, 103613

https://doi.org/10.1016/j.rechem.2026.103613

Design, synthesis, and in vitro anticancer and anti-influenza evaluation of 2-amino-3-benzoyl-N-indolizine-1-carboxamide derivatives

Anatolii Demchenko, Ivan Iurchenko, Volodymyr Zaitsev, Yevhenii Novodvorskyi, Volodymyr Sukhovieiev, Lida Zavodovska, Sergii Demchenko, Sergii Tarnavsky & Sergii Yarmoluk

Chemical Papers (2026)

https://doi.org/10.1007/s11696-026-05188-4

Neurotropic Effects In Vivo of New Tryptamino-Triazines Compared to GABA Effectors

Anatoly Demchenko; Artur Martynov; Yevhenii Novodvorskyi; Oleh Yadlovskyi; Oleh Moskalenko; Tatyana Bomko; Tatyana Nosalsky; Sergii Demchenko; Sergiy Yarmoluk

ACS Chemical Neuroscience, 2025, 16 (24), 4769–4782

https://doi.org/10.1021/acschemneuro.5c00884

Discovery of new aurone derivatives as submicromolar CK2 inhibitors

Mahdysiuk MV, Volynets GP, Bdzhola VG, Bieda OA, Lukashov SS, Sapelkin VM, Karbovskyi LL, Yarmoluk SM

J Enzyme Inhib Med Chem. 2025 Dec; 40(1):2566780. Epub 2025 Oct 9. PMID: 41065365

https://doi.org/10.1080/14756366.2025.2566780

Identification of novel Mycobacterium tuberculosis leucyl-tRNA synthetase inhibitors with antibacterial activity

Volynets GP, Gudzera OI, Lukashov SS, Gorbatiuk OB, Usenko MO, Ruban TP, Protopopov MV, Tarnavskiy SS, Kotey IM, Bdzhola VG, Prykhod'ko AO, Lukash LL, Yarmoluk SM, Tukalo MA

Future Med Chem. 2025 Apr; 17(7):757–765. Epub 2025 Apr 21. PMID: 40259683

https://doi.org/10.1080/17568919.2025.2485673

Probing the Molecular Basis of Aminoacyl-Adenylate Affinity With Mycobacterium tuberculosis Leucyl-tRNA Synthetase Employing Molecular Dynamics, Umbrella Sampling Simulations and Site-Directed Mutagenesis

Volynets GP, Gudzera OI, Usenko MO, Gorbatiuk OB, Bdzhola VG, Kotey IM, Balanda AO, Prykhod'ko AO, Lukashov SS, Chuk OA, Skydanovych OI, Yaremchuk GD, Yarmoluk SM, Tukalo MA

J Mol Recognit. 2025 Mar; 38(2):e3110. Epub 2024 Oct 31. PMID: 39478352

https://doi.org/10.1002/jmr.3110

Syntheses and evaluation of novel 3-hydroxy-1,3-diaryl-2,3,5,6,7,8-hexahydro-imidazo[1,2-a]pyridine-1-ium bromides as potential anticancer agents

Sergii Demchenko, Sergii Yarmoluk, Volodymyr Sukhovieiev, Oleksandr Golovchenko, Oleksandr Sukhovieiev, Anatolii Demchenko

Pharmacia, 2024, 71, 1–10

https://doi.org/10.3897/pharmacia.71.e135992

Fused Triazole-Azepine Hybrids as Potential Non-Steroidal Antiinflammatory Agents

Sergii Demchenko, Roman Lesyk, Oleh Yadlovskyi, Serhii Holota, Sergii Yarmoluk, Sergii Tsyhankov, Anatolii Demchenko

Scientia Pharmaceutica, 2023, 91(2), 26

https://doi.org/10.3390/scipharm91020026

Fluorescent Probes and Dyes

Fluorescent dyes for biomolecule detection, spectroscopy, biosensing and photodynamic applications.

Spectral-fluorescent response of dioxaborine dyes with varying chromophore charge in the presence of serum albumins

Kazakov-Kravchenko OS, Losytskyy MYu, Polishchuk VM, Kulinich AV, Shandura MP, Yarmoluk SM

Biopolym Cell, 2025, 41(3), 222–230

https://doi.org/10.7124/bc.000B1A

Effect of DNA, RNA and HSA on the spectral-luminescent properties of several monomethine cyanine dyes

Kazakov-Kravchenko OS, Balanda AO, Losytskyy MYu, Yarmoluk SM

Biopolym Cell, 2025, 41(2), 121–129

https://doi.org/10.7124/bc.000B16

The squaraine derivatives as potential photosensitizers in photodynamic therapy of cancer

Syniugina AT, Malanchuk OM, Chernii SV, Bdzhola AV, Horbatok KP, Syniugin AR, Yarmoluk SM

Biopolym Cell, 2023, 39(1), 3–13

https://doi.org/10.7124/bc.000A81

Medicinal Plants and Natural Compounds

Phytochemical studies, plant extracts, natural bioactive compounds and their potential biological effects.

In silico modeling and prediction of antidiabetic potential of bioactive compounds from Galega officinalis L. non-alkaloid extract

Maiula TG, Bieda OA, Pylaieva TV, Yarmoluk SM

Biopolym Cell, 2025, 41(4), 309–317

https://doi.org/10.7124/bc.000B29

In silico prediction of neuroprotective properties of natural compounds using Scutellaria baicalensis as an example

Maiula TG, Yarmoliuk SM, Konvaliuk II, Kunakh VA

Biopolym Cell, 2025, 41(2), 139–149

https://doi.org/10.7124/bc.000B18

Chemical composition and effect of Ungernia victoris tissue culture extract on behavioral responses, movement coordination, and pain sensitivity in mice

Stepanova SI, Strygol SYu, Kotsar OO, Bieda OA, Konvalyuk II, Pylaeva TV, Mozhylevska LP, Yarmoluk SM, Kunakh VA

Pharmacol Drug Toxicol, 2025, 19(2)

https://doi.org/10.33250/19.02.157

The hypotensive activity of different fractions of the extracts from tissue culture biomass Rauwolfia serpentina Benth.

Khromov OS, Dobrelia NV, Parshikov OV, Konvalyuk II, Bieda OA, Mozhylevska LP, Yarmoluk SM, Soloviev AI, Kunakh VA

Fiziol Zh, 2023, 69(4), 45–53

https://doi.org/10.15407/fz69.04.045

Point of Contact

Open to Collaboration on Interdisciplinary Biomedical Research.

We are open to collaboration in joint research and applied projects, spanning computational modeling, analytical studies, and hypothesis testing to the publication of findings, joint grant applications, and product development.

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