Projects include the department’s own research and joint initiatives implemented with Ukrainian and international institutions.
01
Investigation of Signaling Cascade Mechanisms in Bcr-Abl-Positive Chronic Myeloid Leukemia as a Basis for the Development of Inhibitors to Overcome Drug Resistance
The project aims to develop new approaches to overcoming drug resistance in the treatment of chronic myeloid leukemia (CML). Bcr-Abl partner proteins and Abl T315I/T315L mutations will be studied to identify new therapeutic targets and inhibitors. The application of computational modeling, virtual screening, and biosensor technologies will contribute to the development of promising tools to improve the effectiveness of CML therapy.
02
Investigation of Mycobacterium tuberculosis Leucyl-tRNA Synthetase Structural Features for Rational Drug Design
The project aims to structurally characterize Mycobacterium tuberculosis leucyl-tRNA synthetase using cryo-electron microscopy and to identify novel inhibitors through molecular dynamics simulations, molecular docking, and machine learning. The results will provide a foundation for the development of potential anti-tuberculosis drugs, particularly against drug-resistant forms of tuberculosis.
03
Biomimetic Humanized Platform for Modeling Multidrug-Resistant Wound Infections and Investigating the Efficacy of Combination Antimicrobial Therapy and Biofilm Structure under Near-in vivo Conditions
An application submitted in May 2025 was selected for funding under the National Research Foundation of Ukraine call “Advanced Science in Ukraine 2026–2028”. Project No. 2025.07/0245 received three-year funding for 2026–2028.
The project aims to create a biomimetic humanized platform that models infected wounds under near-in vivo conditions in order to investigate the pathogenesis of biofilm-associated infections and evaluate new therapeutic strategies for overcoming antimicrobial resistance. A key research focus is extracellular DNA (eDNA), an important biofilm component. Novel fluorescent dyes will be developed to enable high-precision, real-time visualization of eDNA within biofilms. This will support dynamic monitoring of biofilm formation and disruption, including changes induced by combination antimicrobial therapy.
The project is being conducted jointly with Kyiv National University of Technologies and Design.
Let’s Collaborate
Open to Collaboration on Interdisciplinary Biomedical Research
We welcome joint research and applied projects—from computational modelling, analytical studies and hypothesis testing to publications, collaborative grants and new product development.
