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Discovery of novel antituberculosis agents among 3-phenyl-5-(1-phenyl-1H-[1,2,3]triazol-4-yl)-[1,2,4]oxadiazole derivatives targeting aminoacyl-tRNA synthetases

Recently, the article dedicated to the development of novel antituberculosis agents targeting aminoacyl-tRNA synthetases has been published.

Abstract:

Antibiotic resistance is a major...

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Dual targeted hit identification using pharmacophore screening

Recently, the article dedicated to the development of dual-targeted inhibitors of mycobacterial aminoacyl-tRNA synthetases using pharmacophore screening has been...

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Dual-target inhibitors of mycobacterial aminoacyl-tRNA synthetases among N-benzylidene-N'-thiazol-2-yl-hydrazines

Recently, the article dedicated to the development of dual-targeted inhibitors of mycobacterial aminoacyl-tRNA synthetases among N-benzylidene-N'-thiazol-2-yl-hydrazines has been...

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Benzaldehyde thiosemicarbazone derivatives against replicating and nonreplicating Mycobacterium tuberculosis

Recently, the article dedicated to the development of antituberculosis agents based on benzaldehyde thiosemicarbazone derivatives has been published.

Abstract:

In this article, we...

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Our research:

ASK1 Inhibitors
Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as Inhibitors of ASK1 Image
Virtual screening and biochemical screening allowed us to identify...



 

CK2 Inhibitors
4'-hydroxyflavones Image
The novel synthetic flavone inhibitors (4'-hydroxyflavones) were identified...



 

FGFR1 Inhibitors
Oxindoles Image
Oxindoles are known class of inhibitors of RTK, including FGFR1. We perform...



 

Molecular Design
Molecular Design Image
Molecular Design Laboratory of Medicinal Chemistry Department carry out...



 

Fluorescent Probes
Fluorescent dyes for study of beta-pleated protein formations Image
Uncontrolled proteins aggregation is considered to be the molecular basis for a...



 

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