Fluorescent dyes for study of beta-pleated protein formations
Uncontrolled proteins aggregation is considered to be the molecular basis for a range of neurodegenerative diseases, among which Alzheimer's, Parkinson's and Creutzfeldt–Jakob...
Fluorescent detection of partially denatured conformation of beta-lactoglobuline
The native state of many proteins is known to be only marginally stable, correctly folded proteins are in the equilibrium with partially folded conformations and thus can convert to an...
Long-wavelength dyes for fluorescent detection of proteins
Albumins are the major plasma proteins circulating in the bloodstream. Since serum albumin is a reliable prognostic indicator for morbidity and mortality, liver and other diseases and...
Design of fluorescent dyes for biomedical applications
Search and development of novel highly efficient fluorescent probes for biology and medicine are among the main activities of our group. The "lead dye" method, an original approach to...
Dyes for fluorescent detection of non-canonical DNA structures (triplexes and quadruplexes)
In living organisms genomic DNAs mostly exist in a double-stranded (ds) helical form, but occurrence of some other conformations also seems possible. The guanine-rich nucleic acid...