Fluorescent dyes for study of beta-pleated protein formations

Figure 1. Amyloid sensitive cyanine dyes

Uncontrolled proteins aggregation is considered to be the molecular basis for a range of neurodegenerative diseases, among which Alzheimer's, Parkinson's and Creutzfeldt–Jakob...

Fluorescent detection of partially denatured conformation of beta-lactoglobuline

Figure 4. Dyes sensitive to partially unfolded conformations of beta-lactoglobuline.

The native state of many proteins is known to be only marginally stable, correctly folded proteins are in the equilibrium with partially folded conformations and thus can convert to an...

Long-wavelength dyes for fluorescent detection of proteins

Figure 5. Structures of studied squaraine dyes.

Albumins are the major plasma proteins circulating in the bloodstream. Since serum albumin is a reliable prognostic indicator for morbidity and mortality, liver and other diseases and...

Design of fluorescent dyes for biomedical applications

Figure 6. Limits of proteins detection on SDS-polyacrylamide gel by LUCY-506 and LUCY-565 proteins gel stains developed by us for Sigma-Aldrich Inc., in comparison with SYPRO Ruby stain (Invitrogen Corp.).

Search and development of novel highly efficient fluorescent probes for biology and medicine are among the main activities of our group. The "lead dye" method, an original approach to...

Dyes for fluorescent detection of non-canonical DNA structures (triplexes and quadruplexes)

Figure 7. Structures of G-G-C triad in poly(dG-dG)-poly(dC) (A) and G-tetrad in G4-DNA. (B).

In living organisms genomic DNAs mostly exist in a double-stranded (ds) helical form, but occurrence of some other conformations also seems possible. The guanine-rich nucleic acid...

Other fluorescent probes research:

Long-wavelength dyes for fluorescent detection of proteins

Albumins are the major plasma proteins circulating in the bloodstream. Since...

Design of fluorescent dyes for biomedical applications

Search and development of novel highly efficient fluorescent probes for biology...

Fluorescent detection of partially denatured conformation of beta-lactoglobuline

The native state of many proteins is known to be only marginally stable,...