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Non-enzymatic activation of prothrombin induced by interaction with fibrin β26-42 region

In collaboration with the Department of Protein Structure and Functions of Palladin Biochemistry Institute of NAS of Ukraine we have predicted binding mode of β26-44 fibrin fragment with...

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Trimethine cyanine dyes as fluorescent probes for amyloid fibrils: The effect of N,N’-substituents

Our manuscript dedicated to the investigation of trimethine cyanine dyes as fluorescent probes for amyloid fibrils has been published in Analytical...

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A note of caution on the role of halogen bonds for protein kinase/inhibitor recognition suggested by high- and low-salt CK2α complex structures

Our paper in collaboration with Institute of Biochemistry, University of Cologne (Germany), dedicated to the investigation of cocrystal structures of protein kinase CK2 with inhibitor...

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Grant Project “Target-oriented search of aminoacyl-tRNA synthetase inhibitors with selective action toward causative agents of human infectious diseases” has been started

We have started working on project "Target-oriented search of aminoacyl-tRNA synthetase inhibitors with selective action toward causative agents of human infectious diseases" in...

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Our research:

ASK1 Inhibitors

 

CK2 Inhibitors
(thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids (TTP) Image
To study CK2 inhibitory activity of substituted (thieno[2,3-d]...



 

FGFR1 Inhibitors
Flavones Image
One of the first discovered in the screening of inhibitors of FGFR1 classes are...



 

Fluorescent Probes
Dyes for fluorescent detection of non-canonical DNA structures (triplexes and quadruplexes) Image
In living organisms genomic DNAs mostly exist in a double-stranded (ds) helical...



 

Molecular Design
Molecular Design Image
Molecular Design Laboratory of Medicinal Chemistry Department carry out...



 

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