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Design, synthesis and biological evaluation of 5-amino-4-(1H-benzoimidazol-2-yl)-phenyl-1,2-dihydro-pyrrol-3-ones as inhibitors of protein kinase FGFR1

Our paper dedicated to the development of novel inhibitors of protein kinase FGFR1 has been published in Bioorganic and Medicinal Chemistry. 

Abstract: 

Fibroblast growth...

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Contract Research with OTAVA Research and Development Company

Institute of Molecular Biology and Genetics, the NAS of Ukraine has concluded Agreement concerning commercialization of scientific results with OTAVA Research and Development Company Ltd...

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Appeal to Publishers concerning affiliation “Crimea, Russia”

Scientific Researchers of the Department of Medicinal Chemistry of the Institute of Molecular Biology and Genetics, the NAS of Ukraine, support the appeal to publishers which publish...

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Contract Research with Novartis

The Department of Medicinal Chemistry of the Institute of Molecular Biology and Genetics of the NAS of Ukraine has played a leading role in signing of Master Services Agreement with...

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Our research:

CK2 Inhibitors
(thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids (TTP) Image
To study CK2 inhibitory activity of substituted (thieno[2,3-d]...



 

ASK1 Inhibitors
Evaluation of 2-Thioxo-thiazolidin-4-ones Derivatives as Inhibitors of ASK1 Image
In order to discover novel ASK1 inhibitors we have performed screening program,...



 

FGFR1 Inhibitors
Oxindoles Image
Oxindoles are known class of inhibitors of RTK, including FGFR1. We perform...



 

Fluorescent Probes
Long-wavelength dyes for fluorescent detection of proteins Image
Albumins are the major plasma proteins circulating in the bloodstream. Since...



 

Molecular Design
Molecular Design Image
Molecular Design Laboratory of Medicinal Chemistry Department carry out...



 

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