logo
English (United Kingdom)Ukrainian (UA)
ABOUT News and Events Examining c-di-GMP and possible quorum sensing regulation in Pseudomonas fluorescens SBW25: links between intra- and inter-cellular regulation benefits community cooperative activities such as biofilm formation

Examining c-di-GMP and possible quorum sensing regulation in Pseudomonas fluorescens SBW25: links between intra- and inter-cellular regulation benefits community cooperative activities such as biofilm formation

Recently, the article dedicated to the investigation of possible role of bis-(3'-5')-cyclic dimeric  guanosine monophosphate (c-di-GMP) in quorum sensing regulation during biofilm formation in Pseudomonas fluorescens SBW25 has been published. 

Abstract: 

Bacterial success in colonizing complex environments requires individual response to micro-scale conditions as well as community-level cooperation to produce large-scale structures such as biofilms. Connecting individual and community responses could be achieved by linking the intracellular sensory and regulatory systems mediated by bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) and other compounds of individuals with intercellular quorum sensing (QS) regulation controlling populations. There is growing evidence to suggest that biofilm formation by many pseudomonads is regulated by both intra and intercellular systems, though in the case of the model Pseudomonas fluorescens SBW25 Wrinkly Spreader in which mutations increasing c-di-GMP levels result in the production of a robust cellulose-based air-liquid interface biofilm, no evidence for the involvement of QS regulation has been reported. However, our recent review of the P. fluorescens SBW25 genome has identified a potential QS regulatory pathway and other QS-associated genes linked to c-di-GMP homeostasis, and QS signal molecules have also been identified in culture supernatans. These findings suggest a possible link between c-di-GMP and QS regulation in P. fluorescens SBW25 which might allow a more sophisticated and responsive control of cellulose production and biofilm formation when colonising the soil and plant-associated environments P. fluorescens SBW25 normally inhabits. 

  • Examining c-di-GMP and possible quorum sensing regulation in Pseudomonas fluorescens SBW25: links between intra- and inter-cellular regulation benefits community cooperative activities such as biofilm formation (2018). Moshynets OV, Foster D, Karakhim SA, McLaughlin K, Rogalsky SP, Rymar SY, Volynets GP, Spiers AJ. Ukrainian Biochemical Journal 90(3): 17-31. 

Our research:

ASK1 Inhibitors
Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as Inhibitors of ASK1 Image
Virtual screening and biochemical screening allowed us to identify...



 

FGFR1 Inhibitors
Phenylbenzisoxazoles and aminopyrimidines Image
Phenylbenzisoxazoles and aminopyrimidines were also found from virtual...



 

CK2 Inhibitors
3-carboxy-4(1H)-quinolones Image
This CK2 inhibitors were revealed and evaluated to be a CK2 inhibitors after...



 

Fluorescent Probes
Dyes for fluorescent detection of non-canonical DNA structures (triplexes and quadruplexes) Image
In living organisms genomic DNAs mostly exist in a double-stranded (ds) helical...



 

Molecular Design
Molecular Design Image
Molecular Design Laboratory of Medicinal Chemistry Department carry out...



 

© 2012 All rights reserved
footer logo