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Discovery of novel antituberculosis agents among 3-phenyl-5-(1-phenyl-1H-[1,2,3]triazol-4-yl)-[1,2,4]oxadiazole derivatives targeting aminoacyl-tRNA synthetases

Recently, the article dedicated to the development of novel antituberculosis agents targeting aminoacyl-tRNA synthetases has been published.

Abstract:

Antibiotic resistance is a major...

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Dual targeted hit identification using pharmacophore screening

Recently, the article dedicated to the development of dual-targeted inhibitors of mycobacterial aminoacyl-tRNA synthetases using pharmacophore screening has been...

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Dual-target inhibitors of mycobacterial aminoacyl-tRNA synthetases among N-benzylidene-N'-thiazol-2-yl-hydrazines

Recently, the article dedicated to the development of dual-targeted inhibitors of mycobacterial aminoacyl-tRNA synthetases among N-benzylidene-N'-thiazol-2-yl-hydrazines has been...

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Benzaldehyde thiosemicarbazone derivatives against replicating and nonreplicating Mycobacterium tuberculosis

Recently, the article dedicated to the development of antituberculosis agents based on benzaldehyde thiosemicarbazone derivatives has been published.

Abstract:

In this article, we...

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Our research:

FGFR1 Inhibitors
Oxindoles Image
Oxindoles are known class of inhibitors of RTK, including FGFR1. We perform...



 

CK2 Inhibitors
4,5,6,7-tetrahalogeno-1H-isoindole-1,3(2H)-diones (TID) Image
The novel potent and specific CK2 inhibitors -...



 

ASK1 Inhibitors
Evaluation of 2-Thioxo-thiazolidin-4-ones Derivatives as Inhibitors of ASK1 Image
In order to discover novel ASK1 inhibitors we have performed screening program,...



 

Fluorescent Probes
Fluorescent detection of partially denatured conformation of beta-lactoglobuline Image
The native state of many proteins is known to be only marginally stable,...



 

Molecular Design
Molecular Design Image
Molecular Design Laboratory of Medicinal Chemistry Department carry out...



 

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