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Identification of novel small-molecular inhibitors of Staphylococcus aureus sortase A using hybrid virtual screening

Recently, the article dedicated to the development of Staphylococcus aureus sortase A inhibitors using the methods of molecular docking and pharmacophore screening has been...

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Identification of novel antistaphylococcal hit compounds targeting sortase A

Recently, the article dedicated to the development of Staphylococcus aureus sortase A inhibitors possessing antibacterial activity toward multidrug resistant strains has been...

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Discovery of novel antituberculosis agents among 3-phenyl-5-(1-phenyl-1H-[1,2,3]triazol-4-yl)-[1,2,4]oxadiazole derivatives targeting aminoacyl-tRNA synthetases

Recently, the article dedicated to the development of novel antituberculosis agents among 3-phenyl-5-(1-phenyl-1H-[1,2,3]triazol-4-yl)-[1,2,4]oxadiazoles targeting aminoacyl-tRNA...

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Dual targeted hit identification using pharmacophore screening

Recently, the article dedicated to the development of dual-targeted inhibitors of mycobacterial aminoacyl-tRNA synthetases using pharmacophore screening has been...

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Our research:

ASK1 Inhibitors
Evaluation of 2-Thioxo-thiazolidin-4-ones Derivatives as Inhibitors of ASK1 Image
In order to discover novel ASK1 inhibitors we have performed screening program,...



 

FGFR1 Inhibitors
N-phenylnaphthostyril-1-sulfonamides Image
New class of FGFR1 kinase inhibitors with naphthostyril heterocycle has been...



 

CK2 Inhibitors
1,3-thiazole-5-carboxylic acid derivatives Image
Novel CK2 inhibitors among 1,3-thiazole-4-carboxylic acid derivatives have been...



 

Molecular Design
Molecular Design Image
Molecular Design Laboratory of Medicinal Chemistry Department carry out...



 

Fluorescent Probes
Dyes for fluorescent detection of non-canonical DNA structures (triplexes and quadruplexes) Image
In living organisms genomic DNAs mostly exist in a double-stranded (ds) helical...



 

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