Protein Kinase Inhibitor Development

RESEARCH

"Kinome" is a depository of promising drug targets - protein kinases, which control vast diversity of molecular interactions in cell life. Indeed, numerous reports describing the discovery of new pharmaceutical substances targeting protein kinases have been published during last few years. Some of these substances are being tested in clinical trials, some of them are already on the market.

Our Department has been involved in extensive research and development of inhibitors for various protein kinases:

Other kinase inhibitors research:

ASK1 Inhibitors

Evaluation of 2-Thioxo-thiazolidin-4-ones Derivatives as Inhibitors of ASK1

In order to discover novel ASK1 inhibitors we have performed screening program,...

CK2 Inhibitors

(thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids (TTP)

To study CK2 inhibitory activity of substituted (thieno[2,3-d]...

FGFR1 Inhibitors

N-phenylnaphthostyril-1-sulfonamides

New class of FGFR1 kinase inhibitors with naphthostyril heterocycle has been...