logo
English (United Kingdom)Ukrainian (UA)

Oxindoles

Oxindoles are known class of inhibitors of RTK, including FGFR1. We perform searching of FGFR1 inhibitors among available in department collection oxindole compounds. The result has found several active oxindole inhibitors. Based on the oxindole structure search of compounds with similar heterocycles was performed. It found A new class of FGFR1 inhibitors was found, at this time activity of this class optimazed.

Figure 1. Oxindole inhibitor of FGFR1.
Figure 1. Oxindole inhibitor of FGFR1.


  • A.A. Gryshchenko, V.G. Bdzhola, O.V. Borovikov, O.P. Kukharenko, L.V. Pletnyova, S.M. Yarmoluk. Search for FGFR1 inhibitors among oxindole derivatives. Ukrainica Bioorganica Acta 2 (2009) c. 64 – 68

Other kinase inhibitors research:

ASK1 Inhibitors
Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as Inhibitors of ASK1 Image
Virtual screening and biochemical screening allowed us to identify...



 

CK2 Inhibitors
1,3-thiazole-5-carboxylic acid derivatives Image
Novel CK2 inhibitors among 1,3-thiazole-4-carboxylic acid derivatives have been...



 

FGFR1 Inhibitors
Flavones Image
One of the first discovered in the screening of inhibitors of FGFR1 classes are...



 

© 2012 All rights reserved
footer logo