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ASK1 Inhibitors

We have identified three classes of ATP-competitive small-molecular inhibitors of protein kinase ASK1 (apoptosis signal-regulating kinase 1) using computer-based rational design approach.

ASK1 has recently emerged as an attractive therapeutic target for treatment of several human diseases.

It is ground for the search of potential ASK1 inhibitors which can be used in medical practice.

ASK1 overactivity scheme

In order to discover novel ASK1 inhibitors we have performed screening program, using both in silico and in vitro approaches. The virtual screening experiments were carried out targeting the ATP binding site of ASK1 by browsing the Otava Ltd. compound library of 156,000 organic compounds. The best-scored compounds have been selected and taken for the kinase assay study.

We have identified two classes of human ASK1 ATP-competitive inhibitors:

Identification of ASK1 inhibitors among the derivatives of Benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one

ask2_im_4We have identified novel chemical class of ASK1 inhibitors, namely Benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one, using molecular modeling techniques. It was found that...

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Evaluation of 2-Thioxo-thiazolidin-4-ones Derivatives as Inhibitors of ASK1

PFTA-1In order to discover novel ASK1 inhibitors we have performed screening program, using both in silico and in vitro approaches. The system based on DOCK4.0 package was used to study...

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Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as Inhibitors of ASK1

NQDI-1Virtual screening and biochemical screening allowed us to identify small-molecule inhibitor of human protein kinase ASK1 among 3H-naphtho[1,2,3-de]quinoline-2,7-diones. In vitro...

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Other kinase inhibitors research:

ASK1 Inhibitors
Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as Inhibitors of ASK1 Image
Virtual screening and biochemical screening allowed us to identify...



 

CK2 Inhibitors
(thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids (TTP) Image
To study CK2 inhibitory activity of substituted (thieno[2,3-d]...



 

FGFR1 Inhibitors
Quinazolines Image
Quinazolines is another known class of RTK inhibitors that is widely...



 

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