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Rational Design of Apoptosis Signal-Regulating Kinase 1 Inhibitors: Discovering Novel Structural Scaffold

Our manuscript on new ASK1 inhibitors has been published in European Journal of Medicinal Chemistry

Abstract: Increased activity of apoptosis signal-regulating kinase 1 (ASK1)...

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Discovery of New Scaffolds for Rational Design of HCV NS5B Polymerase Inhibitors

Our manuscript on new HCV NS5B Polymerase Inhibitors has been accepted for publcation in European Journal of Medicinal Chemistry

Abstract: Hepatitis C virus (HCV) NS5B...

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Inhibitors of Protein Kinases 2012

On 24-27 August 2012 we participated in 7th International Conference "Inhibitors of Protein Kinases" (IPK'2012) that took place in Warsaw, Poland. Like previous Conferences in this...

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Electrochemical screening of the indole/quinolone derivatives as potential protein kinase CK2 inhibitors

We have published new scientific paper on CK2 inhibitors.

Abstract: An electrochemical method based on the bioorganometallic Fc-ATP cosubstrate for kinase-catalyzed phosphorylation...

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Our research:

CK2 Inhibitors
(thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids (TTP) Image
To study CK2 inhibitory activity of substituted (thieno[2,3-d]...



 

ASK1 Inhibitors
Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as Inhibitors of ASK1 Image
Virtual screening and biochemical screening allowed us to identify...



 

FGFR1 Inhibitors
Phenylbenzisoxazoles and aminopyrimidines Image
Phenylbenzisoxazoles and aminopyrimidines were also found from virtual...



 

Fluorescent Probes
Dyes for fluorescent detection of non-canonical DNA structures (triplexes and quadruplexes) Image
In living organisms genomic DNAs mostly exist in a double-stranded (ds) helical...



 

Molecular Design
Molecular Design Image
Molecular Design Laboratory of Medicinal Chemistry Department carry out...



 

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