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Structure-based discovery of novel flavonol inhibitors of human protein kinase CK2

We have published new scientific paper on CK2 inhibitors. 

Abstract: Serine/threonine protein kinase CK2 controls vast variety of fundamental processes in cell life; however...

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The new class of the human ASK1 inhibitors has been identified by our scientists

Apoptosis signal-regulating kinase 1 (ASK1) has recently emerged as an attractive therapeutic target for the treatment of cardiac and neurodegenerative disorders. The selective inhibitors...

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The new class of potent ATP-competitive inhibitors of the human protein kinase CK2 has been identified

A novel series of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids has been synthesized and tested in vitro towards human protein kinase CK2. It was revealed that the...

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VI International Conference on Protein Kinase CK2

Scientists from Department of Medicinal Chemistry participated in the VI International Conference on Protein Kinase CK2 (07-10 September, 2010, Cologne, Germany). Their oral presentation...

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Our research:

CK2 Inhibitors
4-aminothieno[2,3-d]pyrimidines Image
Novel CK2 inhibitors among 4-aminothieno[2,3-d]pyrimidines have been...



 

ASK1 Inhibitors
Evaluation of 2-Thioxo-thiazolidin-4-ones Derivatives as Inhibitors of ASK1 Image
In order to discover novel ASK1 inhibitors we have performed screening program,...



 

FGFR1 Inhibitors
N-phenylnaphthostyril-1-sulfonamides Image
New class of FGFR1 kinase inhibitors with naphthostyril heterocycle has been...



 

Fluorescent Probes
Fluorescent detection of partially denatured conformation of beta-lactoglobuline Image
The native state of many proteins is known to be only marginally stable,...



 

Molecular Design
Molecular Design Image
Molecular Design Laboratory of Medicinal Chemistry Department carry out...



 

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