logo
English (United Kingdom)Ukrainian (UA)
RESEARCH Protein Kinase Inhibitors FGFR1 Inhibitors Phenylbenzisoxazoles and aminopyrimidines

Phenylbenzisoxazoles and aminopyrimidines

Phenylbenzisoxazoles and aminopyrimidines were also found from virtual screening. Search for analogues of these inhibitors reveal the most active compounds with an IC50 of 5 and 4 mM, respectively. These compounds serve as starting points for further optimization.

Figure 1. Phenylbenzisoxazole and aminopyrimidine inhibitors of FGFR1.Figure 1. Phenylbenzisoxazole and aminopyrimidine inhibitors of FGFR1.

Other kinase inhibitors research:

CK2 Inhibitors
4-aminothieno[2,3-d]pyrimidines Image
Novel CK2 inhibitors among 4-aminothieno[2,3-d]pyrimidines have been...



 

ASK1 Inhibitors
Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as Inhibitors of ASK1 Image
Virtual screening and biochemical screening allowed us to identify...



 

FGFR1 Inhibitors
N-phenylthieno[2,3-d]pyrimidin-4-amines Image
Thienopyrimidine derivatives have attracted great interest as protein kinase...



 

© 2012 All rights reserved
footer logo