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Structure-based discovery of novel flavonol inhibitors of human protein kinase CK2

We have published new scientific paper on CK2 inhibitors. 

Abstract: Serine/threonine protein kinase CK2 controls vast variety of fundamental processes in cell life; however...

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The new class of the human ASK1 inhibitors has been identified by our scientists

Apoptosis signal-regulating kinase 1 (ASK1) has recently emerged as an attractive therapeutic target for the treatment of cardiac and neurodegenerative disorders. The selective inhibitors...

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The new class of potent ATP-competitive inhibitors of the human protein kinase CK2 has been identified

A novel series of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids has been synthesized and tested in vitro towards human protein kinase CK2. It was revealed that the...

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VI International Conference on Protein Kinase CK2

Scientists from Department of Medicinal Chemistry participated in the VI International Conference on Protein Kinase CK2 (07-10 September, 2010, Cologne, Germany). Their oral presentation...

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Our research:

CK2 Inhibitors
1,3-thiazole-5-carboxylic acid derivatives Image
Novel CK2 inhibitors among 1,3-thiazole-4-carboxylic acid derivatives have been...



 

FGFR1 Inhibitors
Flavones Image
One of the first discovered in the screening of inhibitors of FGFR1 classes are...



 

ASK1 Inhibitors
Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as Inhibitors of ASK1 Image
Virtual screening and biochemical screening allowed us to identify...



 

Molecular Design
Molecular Design Image
Molecular Design Laboratory of Medicinal Chemistry Department carry out...



 

Fluorescent Probes
Fluorescent dyes for study of beta-pleated protein formations Image
Uncontrolled proteins aggregation is considered to be the molecular basis for a...



 

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