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Protein Kinase Inhibitor Development
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News and Events
Rational Design of Apoptosis Signal-Regulating Kinase 1 Inhibitors: Discovering Novel Structural Scaffold
Thursday, 13 June 2013
Our manuscript on new ASK1 inhibitors has been published in European Journal of Medicinal Chemistry
Abstract: Increased activity of apoptosis signal-regulating kinase 1 (ASK1)...
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Discovery of New Scaffolds for Rational Design of HCV NS5B Polymerase Inhibitors
Wednesday, 29 August 2012
Our manuscript on new HCV NS5B Polymerase Inhibitors has been accepted for publcation in European Journal of Medicinal Chemistry
Abstract: Hepatitis C virus (HCV) NS5B...
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Inhibitors of Protein Kinases 2012
Friday, 24 August 2012
On 24-27 August 2012 we participated in 7th International Conference "Inhibitors of Protein Kinases" (IPK'2012) that took place in Warsaw, Poland. Like previous Conferences in this...
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Electrochemical screening of the indole/quinolone derivatives as potential protein kinase CK2 inhibitors
Wednesday, 15 February 2012
We have published new scientific paper on CK2 inhibitors.
Abstract: An electrochemical method based on the bioorganometallic Fc-ATP cosubstrate for kinase-catalyzed phosphorylation...
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Our research:
ASK1 Inhibitors
Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as Inhibitors of ASK1
Virtual screening and biochemical screening allowed us to identify...
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CK2 Inhibitors
4'-hydroxyflavones
The novel synthetic flavone inhibitors (4'-hydroxyflavones) were identified...
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FGFR1 Inhibitors
Oxindoles
Oxindoles are known class of inhibitors of RTK, including FGFR1. We perform...
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Fluorescent Probes
Fluorescent detection of partially denatured conformation of beta-lactoglobuline
The native state of many proteins is known to be only marginally stable,...
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Molecular Design
Molecular Design
Molecular Design Laboratory of Medicinal Chemistry Department carry out...
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Phytotherapy of Diseases Integrated Platform
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