logo
English (United Kingdom)Ukrainian (UA)
RESEARCH Protein Kinase Inhibitors

Protein Kinase Inhibitors

"Kinome" is a depository of promising drug targets - protein kinases, which control vast diversity of molecular interactions in cell life. Indeed, numerous reports describing the discovery of new pharmaceutical substances targeting protein kinases have been published during last few years. Some of these substances are being tested in clinical trials, some of them are already on the market.

Our Department has been involved in extensive research and development of inhibitors for various protein kinases:

(thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids (TTP)

Figure 1. The binding mode of TTP22 in the CK2 active site. Hydrogen bonds are shown by the dotted lines.To study CK2 inhibitory activity of substituted (thieno[2,3-d] pyrimidin-4-ylthio)carboxylic acids, 28 compounds of this class were synthesized and tested in vitro. The most active...

Read more...

Page 3 of 3

3
Next
End

Other kinase inhibitors research:

FGFR1 Inhibitors
N-phenylnaphthostyril-1-sulfonamides Image
New class of FGFR1 kinase inhibitors with naphthostyril heterocycle has been...



 

ASK1 Inhibitors

 

CK2 Inhibitors
1,3-thiazole-5-carboxylic acid derivatives Image
Novel CK2 inhibitors among 1,3-thiazole-4-carboxylic acid derivatives have been...



 

© 2012 All rights reserved
footer logo