Наша стаття, присвячена розробці фармакофорної моделі ASK1 на основі різних класів інгібіторів опублікована в журналі Bioorganic and Medicinal Chemistry Letters
Тези: The three-dimensional pharmacophore model of apoptosis-regulating kinase 1 (ASK1) inhibitors has been developed with Pharmagist program. The positions of pharmacophore features in the model correspond to conformations of ASK1 highly active inhibitors in which they interact with ATP-binding site of ASK1. The generated pharmacophore model allows accurately predict active and inactive compounds and can be of great use for virtual screening aimed at discovering novel ASK1 inhibitors.