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RESEARCH Protein Kinase Inhibitors FGFR1 Inhibitors Phenylbenzisoxazoles and aminopyrimidines

Phenylbenzisoxazoles and aminopyrimidines

Phenylbenzisoxazoles and aminopyrimidines were also found from virtual screening. Search for analogues of these inhibitors reveal the most active compounds with an IC50 of 5 and 4 mM, respectively. These compounds serve as starting points for further optimization.

Figure 1. Phenylbenzisoxazole and aminopyrimidine inhibitors of FGFR1.Figure 1. Phenylbenzisoxazole and aminopyrimidine inhibitors of FGFR1.

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