Phytotherapy of Diseases

Development of new agents for the correction of metabolic disorders in diabetes within the framework of ethnopharmacology

Development of new agents for the correction of metabolic disorders in diabetes based on natural multicomponent systems, using artificial intelligence methods, mass spectrometric analysis, and bioinformatics for the search, identification, and prediction of the bioactivity of plant-derived natural compounds.

Particular attention is paid to the creation and standardization of plant compositions with hypoglycemic, antioxidant, and anti-inflammatory effects while preserving the natural synergy of biologically active components. The outcome of this research is the development of scientifically substantiated multicomponent mixtures based on Ukrainian plant raw materials, перспективних for the further development of dietary supplements and potential next-generation medicinal products.

1. Khromov A, Dobrelia N, Konvalyuk I, Bieda O, Andreev I, Mozhylevska L, Yarmoluk S, Soloviev A, Kunakh V (2025) Alkaloid Composition and Antiarrhythmic Activity of the Extracts from Rauvolfia serpentina Tissue Culture. Planta Med 91(12):645-655.
2. Maiula TG, Yarmoliuk SM, Konvaliuk II, Kunakh VA (2025) In silico prediction of neuroprotective properties of natural compounds using Scutellaria baicalensis as an example. Biopolym Cell 41(2):139-149.
3. Maiula TG, Bieda OA, Pylaieva TV, Yarmoluk SM (2025) In silico modeling and prediction of antidiabetic potential of bioactive compounds from Galega officinalis L. non-alkaloid extract. Biopolym Cell 41(4):309-317.
4. Stepanova SI, Strygol SYu, Kotsar OO, Bieda OA, Konvalyuk II, Pylaeva TV, Mozhylevska LP, Yarmoluk SM, Kunakh VA (2025) Chemical composition and effect of Ungernia victoris tissue culture extract on behavioral responses, movement coordination, and pain sensitivity in mice. Pharmacol Drug Toxicol 19(2).
5. Khromov OS, Dobrelia NV, Parshikov OV, Konvalyuk II, Bieda OA, Mozhylevska LP, Yarmoluk SM, Soloviev AI, Kunakh VA (2023) The hypotensive activity of different fractions of the extracts from tissue culture biomassRauwolfia serpentina Benth. Fiziol Zh 69(4):45-53.
6. Kunakh VA, Konvalyuk II, Mozhylevska LP, Bieda OA, Twardovska MO, Andreev IO, Yarmolyuk SM (2023) Comprehensive study of hormone-independent highly productive strain of Rauvolfia serpentina tissue culture as a source of indole alkaloids. Biopolym Cell 39(4):283-298.
7. Ядловський О.Є., Демченко А.М., Конвалюк І.І., Можилевська Л.П., Бєда О.А., Ярмолюк С.М., Кунах В.А. (2022) Дослідження біомаси культури тканин Rauwolfia serpentina Benth. – джерела протиаритмічних і гіпотензивних алкалоїдів на гостру та підгостру токсичність. Фармакологія та лікарська токсикологія 16(4):281-292.
8. Bieda OA, Konvaliuk II, Mozhylevska LP, Lukashov SS, Kunakh VA, Yarmoluk SM (2021) Determination of content of indole alkaloids in cell biomass of Rauwolfia serpentina Benth. ex Kurz tissue culture. Curr Issues Pharm Med Sci Pract 14(1):73-78.
9. Yadlovskyi OYe, Demchenko AM, Konvalyuk II, Mozhylevska LP, Bieda OA, Matiushok VI, Kunakh VA, Yarmoluk SM (2021) Study of the sedative effect of extract from tissue culture biomass of Rauwolfia serpentina. Farm Zh (2):78-86.
10. Monchak IL, Konvalyuk II, Balanda AO, Lukashov SS, Matiushok VI, Kunakh VA, Yarmoluk SM, Soloviev AI (2021) Study of the vasodilatory effect of extract from tissue culture biomass of Rauwolfia serpentina Benth. Farm Zh (3):71-80.